Pestiviruses utilize pyrimidine metabolism to regulate mitophagy for viral replication - PubMed
5 hours ago
- #Autophagy
- #Pestiviruses
- #Antiviral Targets
- DHODH regulates mitophagy, impacting Pestivirus replication, with virus genus specificity in its regulatory mechanism.
- For autophagy-dependent Pestiviruses, DHODH deficiency impairs autophagosome-lysosome fusion, suppressing viral replication.
- Autophagy-inhibiting Flaviviruses benefit from blocked autophagy flux, facilitating their replication.
- DHODH regulates autophagy through pyrimidine nucleotide metabolism; exogenous pyrimidine precursors can restore fusion.
- CSFV NS4A recruits DHODH to mitochondria, interacting with LC3 via the LIR domain to activate mitophagy.
- DHODH is highlighted as a promising antiviral target within the metabolism-autophagy axis.