UHRF1 regulates AR ubiquitination to promote the loss of AR signaling and enzalutamide resistance in progression of prostate cancer - PubMed
6 hours ago
- #UHRF1
- #prostate cancer
- #enzalutamide resistance
- UHRF1 plays a critical role in enzalutamide resistance in prostate cancer by regulating AR ubiquitination and degradation.
- High UHRF1 expression correlates with loss of AR-dependent glandular features in prostate cancer cells.
- Knockdown of UHRF1 increases AR expression and enhances canonical AR signaling pathway activity.
- Combining UHRF1 knockdown with enzalutamide treatment shows synergistic tumor inhibitory effects in vitro and in vivo.
- UHRF1 inhibition restores AR pathway activity and re-sensitizes resistant prostate cancer cells to enzalutamide.
- UHRF1 may serve as a potential therapeutic target for overcoming resistance to AR-targeted therapies.