Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy - PubMed
5 hours ago
- #memory CD8+ T cells
- #brain cancer immunoprevention
- #mRNA-LNP vaccine
- Peripheral vaccination generates brain-resident memory CD8+ T cells (TRM) that protect against intracranial brain tumors.
- Brain TRM, induced via peripheral infection or mRNA-LNP vaccines, provide durable immunity even without circulating memory T cells.
- These TRM persist long-term and offer protection against secondary tumor challenges, supporting immunoprevention strategies for brain cancer.
- The study highlights mRNA-LNP vaccines as a translational approach to bolster brain-specific antitumor immunity.