Single-Cell and Spatial Transcriptomic Profiling Reveals Epithelial Functional States and Fibroblast Phenotypes in Hormone Therapy-Naïve Localized Prostate Cancer - PubMed
5 hours ago
- #single-cell RNA sequencing
- #prostate cancer
- #spatial transcriptomics
- Study focuses on hormone therapy-naïve localized prostate cancer using single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics.
- Reveals heterogeneity in epithelial cells across a malignant spectrum, including patient-unique luminal states and club cell phenotypes.
- Identifies a perineural fibroblast population within the tumor microenvironment (TME).
- Spatial transcriptomics maps the distribution of cancer-associated fibroblasts in the prostate cancer TME.
- Provides a cellular reference for understanding prostate cancer pathobiology and developing a comprehensive disease model.