Conducting polymer-stabilized nanozymes alleviate sepsis-induced myocardial injury by inhibiting iron accumulation and lipid peroxidation - PubMed
5 hours ago
- #septic cardiomyopathy
- #nanozymes
- #ROS scavenging
- Conducting polymer-stabilized nanozymes (PPy-co-PTh) alleviate sepsis-induced myocardial injury by inhibiting iron accumulation and lipid peroxidation.
- A ruthenium-based nanozyme (Ruzyme) from the library exhibits catalase- and superoxide dismutase-like activity, along with nitrogen radical scavenging capability.
- Modification of the conductive interface enhances Ruzyme's catalytic activity and stability by lowering the energy barrier and reducing ROS-induced oxidation.
- Targeted delivery to myocardial mitochondria is achieved using (5-carboxypentyl) triphenyl phosphonium bromide (TPP-COOH) and a cardiac-targeting peptide (CTP).
- In vitro, the nanozymes scavenge ROS, reduce iron accumulation, and inhibit iron-dependent cell death, lowering lipid peroxidation.
- In male SC mice, the nanozymes improve cardiac function, demonstrating therapeutic potential for septic cardiomyopathy.
- The study provides a foundation for developing therapeutic agents for severe cardiomyopathy and related cardiovascular diseases.