Macrophage Mtdh deficiency discordantly regulated tumor growth and metastasis through increased thrombospondin-1 production - PubMed
4 hours ago
- #Macrophage
- #Thrombospondin-1
- #Tumor Metastasis
- Macrophage Mtdh deficiency suppresses lung metastasis but promotes subcutaneous tumor growth in colorectal cancer and melanoma models.
- Increased thrombospondin-1 (TSP-1) production in Mtdh-deficient macrophages leads to anti-angiogenic effects and pro-fibrotic effects via TGF-β1 activation.
- Mtdh knockout disrupts the MDM2-p53 interaction, enhancing p53-dependent TSP-1 transcription.
- Higher TSP-1 expression correlates with advanced pathological T stage and cancer-associated fibroblasts in TCGA colon adenocarcinoma data.
- The study provides insights into the discordant regulation of tumor growth and metastasis by macrophage Mtdh deficiency.