Convergent Oncostatin M and IL-31 Signaling in Chronic Pruritic Dermatoses: A Neuroimmune Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) Perspective - PubMed
4 hours ago
- #chronic pruritus
- #neuroimmune
- #JAK-STAT
- Chronic pruritus (itch) involves complex neuroimmune interactions in skin conditions.
- IL-31 and oncostatin M (OSM) share the OSMRβ receptor and activate JAK1-STAT3 pathways, contributing to chronic itch in diseases like atopic dermatitis and prurigo nodularis.
- IL-31 directly activates sensory neurons via IL-31RA/OSMRβ, while OSM increases neuronal sensitivity through gp130/OSMRβ, but both converge on JAK1-STAT3 signaling.
- Targeting IL-31RA with nemolizumab or OSMRβ with vixarelimab reduces itch severity and improves quality of life, highlighting therapeutic potential.
- Shared IL-31 and OSM pathways provide a framework for understanding itch pathogenesis and guiding future treatments in chronic pruritic dermatoses.