PLSCR3 Deficiency Triggers mtDNA-Driven cGAS-STING Activation to Potentiate Antitumor Immunity in Colorectal Cancer - PubMed
2 hours ago
- #Mitochondrial DNA
- #Immunotherapy
- #Colorectal Cancer
- PLSCR3 deficiency disrupts mitochondrial integrity, leading to cytosolic mtDNA accumulation.
- Cytosolic mtDNA activates the cGAS-STING pathway, enhancing innate immune signaling.
- Activation of cGAS-STING increases cytokine secretion and immune cell cytotoxicity.
- PLSCR3 knockout in MSS CRC models potentiates anti-PD-1 therapy efficacy.
- PLSCR3 is identified as a negative regulator of mtDNA-driven cGAS-STING activation.
- Targeting PLSCR3 could enhance immunotherapy responses in colorectal cancer.