Incidence of all-cause and vaccine-preventable, radiologically confirmed community-acquired pneumonia in hospitalised adults in Germany: a multicentre surveillance study (2021-2023) - PubMed
2 months ago
- #respiratory infections
- #vaccine-preventable diseases
- #community-acquired pneumonia
- Study on incidence of all-cause and vaccine-preventable community-acquired pneumonia (CAP) in hospitalized adults in Germany (2021-2023).
- Prospective, population-based CAP surveillance at three German hospitals.
- Pathogens identified: SARS-CoV-2 (36.5%), S. pneumoniae (9.1%), RSV (3.7%), influenza (1.8%).
- 20-valent pneumococcal conjugate vaccine covered 6.9% of RAD-CAP and 76.0% of pneumococcal CAP cases.
- Overall adjusted annual incidence of all-cause RAD-CAP: 490/100,000 (95% CI 461 to 521).
- Pneumococcal and RSV-related RAD-CAP incidence increased 8.6-fold and 10.0-fold, respectively.
- SARS-CoV-2 related RAD-CAP declined by 70% to 97/100,000 (95% CI 78 to 116).
- High burden of RAD-CAP hospitalizations, especially among older adults.
- Resurgence of CAP due to RSV, S. pneumoniae, or influenza alongside maintained SARS-CoV-2 activity.