Docosahexaenoic acid supplementation aggravates myasthenia gravis through immune dysregulation - PubMed
7 days ago
- #Myasthenia gravis
- #Docosahexaenoic acid
- #Immune dysregulation
- Docosahexaenoic acid (DHA) supplementation worsens myasthenia gravis (MG) by disrupting immune regulation.
- MG is an autoimmune disorder linked to immune cell homeostasis disruption and inflammation.
- Mendelian randomization was used to establish a causal link between serum metabolites and MG.
- Dietary DHA intervention in experimental autoimmune myasthenia gravis (EAMG) rats worsened disease progression and enhanced B cell immune responses.
- DHA increased Treg cell proportion but impaired their inhibitory function via the PI3K-Akt signaling pathway.
- Dysregulated lipid metabolism, particularly elevated DHA levels, is a significant risk factor for MG.
- Modulating lipid metabolism, especially through the PI3K-Akt pathway in Treg cells, could be critical in controlling MG.