Longitudinal analysis of influenza A virus deletion-containing viral genomes reveals key determinants of co-evolutionary dynamics and interference - PubMed
4 hours ago
- #influenza A virus
- #co-evolution
- #deletion-containing viral genomes
- Influenza A virus populations contain diverse deletion-containing viral genomes (DelVGs).
- DelVGs compete with wild-type genomes and may influence disease severity.
- Longitudinal analysis shows early diverse DelVG repertoires contract, leaving only a few persistent high-frequency DelVGs.
- A recurring substitution enhances DelVG replication and interference potency.
- DelVGs are dynamic and shape viral population dynamics through unique selection forces.