Lack of impact of antibiotics and proton pump inhibitors on the efficacy of preoperative chemoimmunotherapy in locally advanced non-small cell lung cancer: A multicenter retrospective study - PubMed
6 hours ago
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- Antibiotics and proton pump inhibitors (PPIs) do not significantly affect the efficacy of preoperative chemoimmunotherapy in locally advanced non-small cell lung cancer (NSCLC).
- The study involved 131 patients with resectable stage II-III NSCLC who received neoadjuvant chemoimmunotherapy with nivolumab, with 113 undergoing definitive surgery.
- No significant differences were found in pathological complete response (pCR), major pathological response (MPR), or objective response rate (ORR) between users and non-users of antibiotics or PPIs.
- The study concludes that prior use of antibiotics and PPIs does not impact the radiological or pathological response to neoadjuvant immune checkpoint inhibitors in resectable NSCLC.
- Further research with larger sample sizes and longer follow-up periods is recommended to confirm these findings.