Differential patterns of central synucleinopathy and catecholaminergic abnormalities in Lewy body diseases and multiple system atrophy - PubMed
5 hours ago
- #biomarkers
- #synucleinopathy
- #neurodegenerative diseases
- The study examines differential patterns of central synucleinopathy and catecholaminergic abnormalities in Lewy body diseases (LBDs) and multiple system atrophy (MSA).
- CSF alpha-synuclein seed amplification assays (SAAs) by RML and Amprion effectively distinguished PD and PAF from MSA.
- Amprion's assay identified type 1 seeding (LBD-associated) in 92% of PD and 94% of PAF patients, and type 2 seeding (MSA-associated) in 90% of MSA-P and 75% of MSA-C patients.
- 18F-DOPA PET revealed low putamen/occipital cortex ratios in all PD and MSA-P patients, while PAF and MSA-C patients mostly had normal ratios.
- Combining CSF SAA and 18F-DOPA PET effectively differentiated PD, PAF, MSA-P, and MSA-C groups.
- Cardiac 18F-dopamine PET distinguished LBDs from MSA but not PAF from PD or MSA-P from MSA-C.
- The study highlights the utility of combined biomarkers in differentiating synucleinopathies.