Polydopamine-Encapsulated Probiotics Restore Gut Homeostasis and Reinstate Macrophage Efferocytosis in Systemic Lupus Erythematosus - PubMed
2 days ago
- #probiotics
- #autoimmunity
- #microbiome
- Polydopamine-coated Lactobacillus rhamnosus GG (LGG@PDA) improves probiotic viability and resistance in the gut.
- LGG@PDA treatment in lupus mice restores gut homeostasis, enhances macrophage efferocytosis, and reduces autoantibodies.
- L-methionine, a metabolite enriched by LGG@PDA, enhances macrophage efferocytosis via CX3CR1, aiding immune tolerance.
- The study highlights LGG@PDA as a bioengineered probiotic platform for microbiota modulation and immune regulation in SLE.
- Findings suggest L-methionine as a key metabolic mediator and a potential therapeutic target for SLE.