The immunometabolic topography of cellular organization and bacterial control in tuberculosis granulomas - PubMed
5 hours ago
- #immunometabolism
- #tuberculosis
- #granuloma
- Tuberculosis (TB) granulomas often evade host immune responses, enabling Mycobacterium tuberculosis (Mtb) persistence.
- Human TB granulomas contain immunosuppressive factors similar to those in tumor-immune evasion, suggesting a tolerogenic niche.
- A study analyzed 52 granulomas from 16 nonhuman primates infected with Mtb, correlating granuloma structure with bacterial burden.
- TB granulomas universally partition the myeloid core into two metabolic environments, one of which is hypoxic.
- Hypoxia in granulomas is linked to dysfunctional immune cell states, poor lymphocyte infiltration, and higher bacterial burden.
- The extent of hypoxia-associated features correlates with reduced infection control and immune subversion in TB granulomas.