Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging - PubMed

4 hours ago

Piezo1-dependent activation of stromal cells triggers muscle inflammation in response to exercise and injury.
The mechanosensitive ion channel Piezo1 is identified as the primary molecular sensor for mechanical stress in muscle mesenchymal stromal cells.
Mechanosensing by stromal cells is crucial for inflammatory and myogenic responses to muscle injury and is linked to age-related muscle inflammation.
The study highlights Piezo1's role in sensing tissue stiffness as a key mechanism of stress-induced immunomodulation in skeletal muscle.

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