CoQ10 oxidoreductases in ferroptosis and cancer: redox regulation and therapeutic opportunities - PubMed
4 hours ago
- #ferroptosis
- #cancer therapy
- #redox regulation
- CoQ10 is a redox cofactor involved in mitochondrial electron transport and oxidative stress protection.
- CoQ10 and its oxidoreductases are critical regulators of ferroptosis, an iron-dependent cell death driven by lipid peroxidation.
- Enzymes like FSP1, DHODH, and SQOR suppress ferroptosis by regenerating reduced ubiquinol (CoQ10H2).
- The review updates the CoQ10 biosynthetic pathway and functions of key oxidoreductases.
- Newly identified CoQ10-related enzymes and their roles in ferroptosis regulation are discussed.
- CoQ10 oxidoreductases are positioned as promising targets for ferroptosis-based cancer therapies.