Exploring Chinese Herbal Medicines for Acute Kidney Injury: Pharmacological Mechanisms and Clinical Potential - PubMed
5 hours ago
- #acute kidney injury
- #renal protection
- #Chinese herbal medicine
- Acute kidney injury (AKI) is a serious condition with high morbidity and mortality, lacking effective pharmacologic therapies.
- Chinese herbal medicines (CHMs) show promise in treating AKI through anti-inflammatory, antioxidant, anti-apoptotic, and mitochondrial-protective mechanisms.
- Key pathways targeted by CHMs include NF-κB, Nrf2, PI3K/Akt, MAPK, and apoptotic regulators like Bcl-2/Bax and caspases.
- Notable CHMs include berberine, baicalin, puerarin, and multi-herb formulas like QiShenYiQi and Jianpi Yishen Tang.
- Preclinical studies are encouraging, but robust clinical trials and formulation standardization are needed for validation and safety.
- Integrating CHMs into modern nephrology could enhance AKI treatment options and advance nature-derived therapies.