Condensed vs. Standard Step-Up Dosing Schedule of Talquetamab in Relapsed/Refractory Multiple Myeloma - PubMed
6 hours ago
- #cytokine release syndrome
- #multiple myeloma
- #bispecific antibody
- The study compares a condensed step-up dosing (SUD) schedule (Days 1, 3, 5, 7) with the standard SUD schedule (Days 1, 4, 7, 10) for talquetamab in relapsed/refractory multiple myeloma.
- No significant differences were found in the incidence or severity of cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) between the two schedules.
- The condensed SUD schedule is feasible and well-tolerated in routine clinical practice, suggesting it can be used as an alternative to the standard schedule.