Cnpy1 is a candidate endoplasmic reticulum chaperone of vomeronasal type 2 GPCRs - PubMed
5 hours ago
- #Cnpy1
- #GPCR
- #ER chaperone
- Cnpy1 is identified as a candidate endoplasmic reticulum (ER) chaperone for vomeronasal type 2 GPCRs (V2Rs).
- Cnpy1 is selectively expressed in Gαo neurons and localizes to the ER, associating specifically with V2R GPCRs and other ER chaperones.
- Deletion of Cnpy1 leads to deficient Gαo neuronal activation and reduced male-male aggressive behavior in mice.
- Cnpy1-null mice show selective, progressive apoptosis of Gαo neurons postnatally, without obvious unfolded protein response or defects in V2R trafficking.
- Cnpy1 is essential for V2R assembly or functional maturation but not for their ER export, highlighting its role in Gαo neuron signaling and survival.