Plasma eMTBR-tau243 and %p-tau217 for Biological Staging of Alzheimer Disease - PubMed
5 hours ago
- #Plasma Biomarkers
- #Biological Staging
- #Alzheimer's Disease
- Plasma biomarkers %p-tau217 and eMTBR-tau243 were used to develop a biological staging model for Alzheimer's disease.
- The model showed high concordance with PET-based staging (C index 0.91) and clinical stages within the AD continuum.
- Validation in independent cohorts confirmed strong alignment with PET staging and neuropathological autopsy data.
- The combined biomarker model improved classification accuracy over %p-tau217 alone, especially for intermediate disease stages.
- This minimally invasive approach could enable broader clinical use of biological staging for diagnosis and treatment selection.