A periplasmic protein complex mediates arabinofuranosyltransferase activity and intrinsic drug resistance in Mycobacterium tuberculosis - PubMed
18 hours ago
- #tuberculosis
- #drug resistance
- #cell envelope
- A periplasmic protein complex (FecB and Rv3035) maintains envelope integrity and mediates intrinsic multidrug resistance in Mycobacterium tuberculosis.
- The FecB-Rv3035 complex interacts with AftB, an arabinofuranosyltransferase, supporting its enzymatic activity in synthesizing key cell envelope components like arabinogalactan and lipoarabinomannan.
- Structural analysis reveals critical residues for FecB-Rv3035 complex formation, and genetic studies confirm a functional link between these proteins and AftB in drug resistance and virulence.
- Loss of FecB or Rv3035 disrupts arabinan synthesis and impairs Mtb virulence in mice, highlighting their roles as potential therapeutic targets against tuberculosis.