Metformin Alters Exercise Training Induced Blood Pressure and Aortic Waveform Adaptations in Adults at Risk for Metabolic Syndrome - PubMed
2 days ago
- #metformin
- #blood pressure
- #exercise
- Metformin's impact on blood pressure and aortic waveforms in adults at risk for metabolic syndrome was studied.
- A double-blind, placebo-controlled trial compared low and high-intensity exercise with and without metformin over 16 weeks.
- Metformin combined with high-intensity exercise reduced fasting peripheral diastolic blood pressure.
- Insulin-stimulation led to increased peripheral diastolic blood pressure and reflection magnitude in metformin groups.
- Metformin was associated with higher fasting levels of inflammatory markers MMP-1 and MMP-7.
- The study concludes metformin alters blood pressure and aortic waveform adaptations post-exercise, linked to inflammation.