PRMT5/Sohlh2/Sirt1 Signaling Pathway in Vascular Endothelial Cells Modulates Lung Metastasis of Triple-Negative Breast Cancer - PubMed
5 hours ago
- #Triple-negative breast cancer
- #Lung metastasis
- #Vascular endothelial cells
- Lung metastasis is a major cause of death in triple-negative breast cancer (TNBC) patients.
- Sohlh2, a tumor suppressor gene, plays a crucial role in the interaction between vascular endothelial cells (VECs) and TNBC cells.
- Low Sohlh2 expression in VECs is linked to poor prognosis and metastasis in TNBC patients.
- Overexpression of Sohlh2 in VECs reduces TNBC cell adhesion, trans-endothelial migration, and endothelial cell senescence.
- Sohlh2 in VECs suppresses TNBC lung metastasis by repressing NF-κB signaling via promoting Sirt1 transcription.
- PRMT5-mediated arginine methylation of Sohlh2 leads to its degradation, inhibiting its protective effects in VECs.
- The PRMT5/Sohlh2/Sirt1 signaling pathway in VECs is a potential therapeutic target for TNBC metastasis.