Impact of EV-A71 vaccination and non-pharmaceutical interventions on hand, foot, and mouth disease: A 14-year interrupted time series analysis - PubMed
6 hours ago
- #HFMD epidemiology
- #non-pharmaceutical interventions
- #EV-A71 vaccine
- EV-A71 vaccination introduced in 2016 led to a 33% reduction in hand, foot, and mouth disease (HFMD) incidence and prevented 23.8% of potential cases over eight years.
- Stringent non-pharmaceutical interventions (NPIs) during 2020-2022 resulted in an 84% reduction in HFMD incidence and prevented 82.6% of expected cases, but policy relaxation caused a significant rebound in cases.
- Pathogen surveillance showed a decline in EV-A71 prevalence from 30.5% to 4.5% post-vaccination, with coxsackievirus A6 emerging as the dominant serotype, highlighting serotype replacement and gaps in prevention strategies.