High-Sensitivity Cardiac Troponin T-gen6 Assay in Suspected Myocardial Infarction: Diagnostic Accuracy, Cutoffs, and Clinical Implications - PubMed
5 hours ago
- #Myocardial Infarction Diagnosis
- #Clinical Validation
- #Cardiac Troponin Assay
- The hs-cTnT-gen6 assay demonstrates comparable diagnostic accuracy to the hs-cTnT-gen5 assay, with an area under the curve of 0.927 vs. 0.931.
- Fewer patients are identified with myocardial injury using hs-cTnT-gen6 (35.9%) compared to hs-cTnT-gen5 (43.5%).
- Optimized cutoffs for the ESC 0/1- and 0/2-hour algorithms provide high sensitivity (up to 100%) and specificity (up to 93.4%) for ruling out and ruling in myocardial infarction.
- The gen6 cutoff of <6 ng/L rules out non-ST-segment elevated myocardial infarction in 30.0% of patients with 100% sensitivity, regardless of chest pain onset.
- Findings were consistent in sensitivity analyses and external validation, supporting the clinical applicability of the new assay.