Mitochondrial cristae density is increased following high-intensity interval training in men with type 2 diabetes - PubMed
4 days ago
- #Mitochondrial Cristae
- #High-Intensity Interval Training
- #Type 2 Diabetes
- Mitochondrial cristae density increases after high-intensity interval training (HIIT) in men with type 2 diabetes.
- No baseline differences in mitochondrial cristae density were found between individuals with type 2 diabetes, glucose-tolerant obese individuals, and lean individuals.
- HIIT induced a ~7% increase in cristae density across all groups, with the most pronounced changes in type 2 muscle fibers and the intermyofibrillar compartment.
- Participants with type 2 diabetes initially had lower cristae surface area per muscle volume compared to lean individuals.
- HIIT increased cristae surface area per muscle volume by ~55%, surpassing previous increases in mitochondrial volume density.
- The study highlights the plasticity of mitochondrial architecture and supports HIIT as an effective intervention for improving metabolic health in type 2 diabetes.