Single-Cell and Spatial Transcriptomics Uncover Immune Dynamics and Cellular Heterogeneity in Benign Prostatic Hyperplasia and Prostate Cancer Transition - PubMed
6 hours ago
- #Single-Cell Transcriptomics
- #Prostate Cancer
- #Immune Microenvironment
- Single-cell RNA sequencing and spatial transcriptomics reveal a continuous transformation of luminal epithelial cells from benign prostatic hyperplasia (BPH) to prostate cancer (PCa).
- During progression to PCa, the immune microenvironment remains suppressive, with T cells showing high infiltration but activation retardation and functional exhaustion.
- Macrophages in lesion nodules are significantly infiltrated and exhibit M2 polarization, activating inflammatory signaling pathways related to immune escape.
- NK cells and B cells are partially activated, but their low abundance limits their functional impact in the tumor context.
- These findings provide insights for immunotherapy and personalized treatment strategies, aiding in early diagnosis and intervention for PCa.