Prognostic and therapeutic implications of BRAF mutations in acute myeloid leukemia - PubMed
4 hours ago
- #targeted therapy
- #BRAF mutations
- #acute myeloid leukemia
- BRAF mutations are found in about 1% of AML cases and are linked to poor outcomes.
- These mutations are more common in myelodysplasia-related AML (AML-MR) and often occur outside the V600 hotspot.
- Single-cell multiomic analysis shows BRAF mutations co-occur with other signaling mutations within the same cells.
- Patients with BRAF-mutant AML have poor overall survival even with current treatments like venetoclax-based regimens.
- Drug sensitivity data suggests potential targeted therapies for BRAF-mutated AML.