Linking bone and brain: Dysregulated bone metabolism exacerbates cognitive impairment in bipolar disorder - PubMed
5 hours ago
- #bipolar-disorder
- #cognitive-impairment
- #bone-brain-axis
- Study explores the link between bone metabolism, bone mineral density (BMD), and cognitive performance in drug-naive bipolar disorder (BD) patients.
- 202 drug-naïve BD patients and 161 healthy controls (HCs) were assessed for BMD, bone turnover markers, vitamin D, and cognitive function.
- BD patients showed higher PINP/OC, lower vitamin D, lower BMD, and poorer cognition (attention, memory, executive function) compared to HCs.
- CTX-I (a bone turnover marker) negatively correlated with cognitive scores, while BMD positively associated with language functions.
- Age and PINP were significantly associated with differences between BD patients and HCs, while CTX-I and semantic fluency showed opposite associations.
- The classification model achieved an AUC of 0.882, with cognitive measures, age, and bone metabolism markers strongly linked to group differences.
- Findings support the 'bone-brain axis' hypothesis, suggesting abnormal bone metabolism may exacerbate cognitive impairment in BD.