Liver-Pancreas Fat Deposition: Impact on Cardiometabolic Multimorbidity and Cardiac Dysfunction - PubMed
8 days ago
- #pancreatic steatosis
- #cardiometabolic multimorbidity
- #MASLD
- Metabolic dysfunction-associated steatotic liver disease (MASLD) and pancreatic steatosis (PS) are interconnected ectopic fat conditions linked to cardiometabolic dysregulation.
- The study examined cross-sectional associations between PS and MASLD severity in a biopsy-proven cohort from China and assessed long-term risks in the UK Biobank cohort.
- Findings showed that PS is associated with severe hepatic steatosis, lobular inflammation, and fibrosis in MASLD patients.
- Coexistence of MASLD and PS additively increased the risk of new-onset cardiometabolic multimorbidity (CMM) and was linked to cardiac structural and functional alterations.
- Proteomic profiling revealed upregulation of lysosomal catabolic and glycosaminoglycan-degrading pathways in dual-organ steatosis, with heparan sulphate proteoglycan catabolism as a hallmark.
- Conclusion: PS is linked to greater MASLD severity, and dual-organ involvement (liver and pancreas) increases CMM risk and cardiac remodeling.