Thymus regeneration therapies: entering a new era - PubMed
7 hours ago
- #thymus regeneration
- #stem cell therapy
- #immune reconstitution
- The thymus is essential for T cell development, but its function declines with age.
- Genetic defects affecting the thymus can cause immunodeficiency and autoimmunity.
- Allogeneic thymus transplantation for congenital athymia faces challenges like donor availability and HLA mismatch.
- Advances in stem cell engineering enable scalable thymus regeneration using iPSC-derived thymic epithelial cells.
- Thymus regeneration therapies have potential to treat immune deficiency, transplantation, cancer, autoimmunity, and aging.