Amino acid metabolism modulates macrophage polarization: implications for autoimmune-related diseases - PubMed
5 hours ago
- #immunometabolism
- #autoimmune diseases
- #macrophage polarization
- Amino acid metabolic reprogramming is a key aspect of immunometabolism that influences macrophage polarization through various mechanisms like redox regulation and epigenetic changes.
- Specific amino acid pathways—including arginine, tryptophan, glutamine, and others—orchestrate macrophage functional states, impacting inflammatory and reparative roles in autoimmune diseases.
- The review connects amino acid metabolism to autoimmune conditions such as systemic lupus erythematosus and rheumatoid arthritis, highlighting potential for novel biomarkers and therapies.
- Amino acid metabolism interacts with other metabolic networks like glycolysis and lipid metabolism to collectively determine macrophage fate and disease outcomes.
- Clinical translation of these findings requires caution due to differences between experimental models and human studies, necessitating further validation for therapeutic applications.