Understanding selective aminopenicillin allergy: findings from a long-term case series - PubMed
4 hours ago
- #β-lactam allergy
- #drug hypersensitivity
- #aminopenicillin allergy
- Retrospective study on selective aminopenicillin allergy from 2018-2024.
- 167 out of 1,340 patients (12.5%) had confirmed selective aminopenicillin allergy.
- Predominantly affected middle-aged women with immediate reactions like urticaria/angioedema and anaphylaxis.
- Standardized diagnostic work-up included skin prick, intradermal tests, patch tests, specific IgE measurement, and drug challenge tests (DCT).
- Intradermal testing and DCT were most informative; specific IgE contributed minimally.
- All patients tolerated penicillin V during DCT, confirming selective sensitization to the aminopenicillin side chain.
- Supports safe use of other β-lactams in this population.
- Highlights importance of comprehensive diagnostic algorithms for antibiotic stewardship and expanding therapeutic options.