AKT1 phosphorylates PRMT7 to promote GLUD1 methylation and gastric cancer progression - PubMed
8 hours ago
- #GLUD1 methylation
- #PRMT7 phosphorylation
- #Gastric cancer
- AKT1 phosphorylates PRMT7 at T73, enhancing PRMT7 activity.
- PRMT7 mediates monomethylation of GLUD1 at R76, increasing GLUD1 stability by reducing ubiquitination.
- Elevated GLUD1, PRMT7, and meGLUD1(R76) levels correlate with gastric cancer progression.
- PRMT7 inhibitor SGC3027 combined with docetaxel synergistically suppresses tumor growth in models.