SECmeres outperform extracellular vesicles as potential blood RNA biomarkers for Alzheimer's disease - PubMed
4 hours ago
- #Alzheimer's disease
- #biomarkers
- #extracellular vesicles
- SECmeres are sub-50nm brain-derived nanoparticles distinct from small EVs like exosomes, lacking typical EV markers.
- RNA from SECmeres discriminates Alzheimer's disease cases from controls more effectively than small EVs, with large EVs showing no difference.
- SECmeres enrich brain endothelial transcripts related to the blood-brain barrier, while small EVs contain RNAs from diverse brain cells.
- The findings suggest SECmeres may be superior blood-based RNA biomarkers for Alzheimer's disease, challenging the focus on small EVs.
- Further validation in larger blinded clinical trials is needed to confirm SECmeres' potential for non-invasive liquid biopsy.