Neuropeptide-GPCR Regulation of the Neuroimmune Axis in Neurodegeneration: Mechanisms and Translation - PubMed
5 days ago
- #Neuropeptides
- #Neurodegeneration
- #Neuroinflammation
- Chronic neuroinflammation and dysfunction of the neuro-glial-vascular unit (NGVU) drive neurodegenerative diseases like Alzheimer's and Parkinson's.
- Neuropeptides regulate inflammatory activation, phagocytosis, autophagy, metabolic homeostasis, and blood-brain barrier function via GPCRs.
- Key neuropeptides include NPY, VIP/PACAP, SP, and CGRP, which contribute to CNS homeostasis and disease processes.
- The review integrates preclinical and human data to link neuropeptides to disease progression mechanisms.
- Translational research focuses on ligand engineering, targeted delivery, and biomarker-guided therapy for precise immune regulation.