STING1 exacerbates iodinated contrast-induced acute kidney injury by promoting ferroptosis through chaperone-mediated autophagic degradation of FTH1 - PubMed
6 hours ago
- #acute kidney injury
- #STING1
- #ferroptosis
- STING1 exacerbates iodinated contrast-induced acute kidney injury (CI-AKI) by promoting ferroptosis.
- Ferroptosis is driven by iron overload and lipid peroxidation, contributing to CI-AKI.
- STING1 activation by iodinated contrast media (ICM) triggers ferroptosis in renal proximal tubular cells (RPTCs).
- Sting1 deficiency in knockout mice and primary RPTCs mitigates ferroptosis and alleviates CI-AKI.
- STING1 interacts with HSPA8/HSC70, facilitating chaperone-mediated autophagic degradation of FTH1 and GPX4.
- Inhibition of chaperone-mediated autophagy (CMA) via LAMP2A knockdown prevents FTH1 and GPX4 degradation, reducing ferroptosis.
- The study highlights STING1 as a potential therapeutic target for contrast-induced renal injury.