Regulatory elements in the Sox9 locus license the initiation of pancreatic ductal adenocarcinoma - PubMed
5 hours ago
- #pancreatic cancer
- #super-enhancers
- #Sox9
- Cellular plasticity can be hijacked by oncogenic programs, with Kras acting on pancreas-specific enhancers to drive cancer initiation.
- LINC00673, a lncRNA from a Sox9-associated super-enhancer, is reactivated in pancreatic ductal adenocarcinoma (PDAC) and influences its initiation.
- Deletion of LINC00673 accelerates resolution of acinar-to-ductal metaplasia and impairs PDAC initiation.
- Transcribed super-enhancers contribute to long-range gene regulation during pancreatic cancer initiation.
- A regulatory layer links developmental enhancer activity, cellular plasticity, and pancreatic disease progression.