Efficacy of dental stem cell-derived exosomes for pulp regeneration: a systematic review of clinical, animal, and in vitro studies - PubMed
6 hours ago
- #exosomes
- #dental stem cells
- #pulp regeneration
- Dental stem cell-derived exosomes (DSC-Exos) are promising for pulp-dentin regeneration due to their roles in angiogenesis, odontoblastic differentiation, and immune regulation.
- A systematic review evaluated DSC-Exos' regenerative potential, identifying key factors like donor-cell preconditioning and biodegradable carriers that enhance outcomes.
- Studies showed DSC-Exos promote cell proliferation, migration, and upregulation of odontogenic (DSPP, DMP1) and angiogenic (VEGF, CD31) markers.
- Animal models demonstrated formation of vascularized pulp-like tissue and organized tubular dentin, linked to noncoding RNAs and signaling pathways like miR-26a/TGF-β.
- A 24-month clinical pilot confirmed restored pulp sensitivity without safety concerns, though evidence certainty remains moderate to low due to methodological heterogeneity.
- Standardized protocols, dose harmonization, and long-term clinical trials are needed before DSC-Exos can be reliably used in clinical practice.