A systematic review and meta-analysis of the auditory steady-state response in schizophrenia, bipolar disorder, and autism spectrum disorder - PubMed
3 months ago
- #psychiatric-disorders
- #biomarker
- #neuroscience
- The 40-Hz auditory steady-state response (ASSR) is a potential biomarker for schizophrenia (SZ), bipolar disorder (BD), and autism spectrum disorder (ASD).
- Meta-analysis included 52 studies with 2116 SZ patients, 271 clinical high-risk for psychosis (CHR-P), 110 first-degree relatives of SZ patients (FDR-SZ), 294 BD patients, 117 ASD patients, and 2758 healthy controls (HC).
- Reductions in power and inter-trial phase coherence (ITPC) of 40-Hz ASSR were observed in SZ, BD, and power reduction in ASD compared to HC.
- FDR-SZ showed reduced 40-Hz ASSR power and ITPC, but CHR-P did not.
- SZ patients exhibited power reductions in 80-Hz ASSR and reduced ITPC in 20-Hz ASSR, while BD patients did not show 20-Hz ITPC deficits.
- 40-Hz ASSR may serve as a biomarker for psychotic disorders, while 20-Hz and 80-Hz deficits may be specific to schizophrenia.
- Further studies are needed to confirm these findings.