Biogenesis, preparation, characterization, therapeutic mechanisms and safety evaluation of plant-derived exosome-like nanovesicles in the treatment of ulcerative colitis - PubMed
5 hours ago
- #phytotherapy
- #ulcerative colitis
- #nanomedicine
- Plant-derived exosome-like nanovesicles (PDELNs) are emerging as a promising treatment for ulcerative colitis due to their biocompatibility and bioactive cargo.
- PDELNs are isolated using centrifugation techniques like ultracentrifugation, differential centrifugation, and density gradient centrifugation.
- Therapeutic mechanisms of PDELNs include anti-inflammatory effects, gut microbiota remodeling, and immune response regulation.
- Key bioactive components in PDELNs are plant microRNAs, metabolites, and lipids, contributing to their therapeutic effects.
- PDELNs demonstrate an excellent safety profile with no reported toxicity, making them a viable next-generation therapeutic option.
- PDELNs bridge traditional phytotherapy and modern nanomedicine, offering multi-targeted mechanisms for colitis treatment.