Rat Models of Thrombotic Thrombocytopenic Purpura Reveal Crucial Role of Placental ADAMTS13 in Perinatal Survival - PubMed
6 hours ago
- #Thrombotic Thrombocytopenic Purpura
- #ADAMTS13
- #Rat Models
- Rat model of TTP created by CRISPR/Cas9 deletion of ADAMTS13 metalloprotease.
- KO rats showed severe ADAMTS13 deficiency, increased VWF multimers, and spontaneous thrombocytopenia.
- Elevated lactate dehydrogenase, urea nitrogen, and creatinine levels in KO rats.
- Microvascular thrombi found in major organs of KO rats.
- Pregnancy/postpartum did worsen thrombocytopenia but increased mortality risk in KO females bred with KO males.
- KO females bred with KO males produced fewer live offspring compared to those bred with WT/Het males.
- Model recapitulates congenital TTP and highlights fetal-placental ADAMTS13 role in perinatal survival.