Inflammation reprograms fibro-adipogenic progenitors to sustain immunopathogenic niches in myositis - PubMed
5 hours ago
- #myositis
- #stromal cells
- #immune niches
- Fibro-adipogenic progenitors (FAPs) sustain inflammatory niches in idiopathic inflammatory myopathies (IIMs) by adapting to local immune cell environments.
- FAPs co-localize with muscle stem cells and activated macrophages, facilitating communication with immune and muscle cells.
- TGF-β from immune cells and EGF from myofibers drive FAP differentiation into pro-inflammatory and pro-fibrotic phenotypes via AP-1 transcription factor.
- Exposure to TGF-β and EGF alters AP-1 regulatory element accessibility in human FAPs, priming them for an inflammatory role.
- FAPs represent a promising therapeutic target for myositis by disrupting microenvironmental cross-talk in muscle inflammation.