Medical thoracoscopy with talc poudrage and indwelling pleural catheter insertion versus medical thoracoscopy with talc poudrage alone for patients with symptomatic malignant pleural effusion (TACTIC)
5 hours ago
- #indwelling pleural catheter
- #malignant pleural effusion
- #medical thoracoscopy
- The TACTIC trial compared medical thoracoscopy with talc poudrage plus indwelling pleural catheter (IPC) insertion versus talc poudrage alone for malignant pleural effusion (MPE) patients.
- Primary outcomes were hospital stay length and dyspnoea severity over 4 weeks, with no significant difference found between groups.
- IPC insertion led to fewer additional invasive pleural procedures by 12 weeks (3% vs 34%, p<0.0001).
- Both approaches showed similar safety profiles, with three serious adverse events in the IPC group.
- Combining IPC with poudrage did not reduce hospital stay but may benefit patients prioritizing fewer invasive procedures.