PFKM governs metabolic shifts throughout skeletal muscle differentiation - PubMed
6 hours ago
- #PFKM
- #glycolysis
- #skeletal muscle differentiation
- PFKM, the muscle isoform of PFK1, plays a crucial role in metabolic shifts during skeletal muscle differentiation.
- Wnt signaling induces lysosomal degradation of PFKM via a methyl arginine degron motif, mediated by PRMT1 and microautophagy.
- PFKM degradation shifts glucose metabolism from glycolysis to the pentose phosphate pathway.
- Overexpression of PFKM increases glycolysis and promotes differentiation into myofibers.
- Knockdown of PFKM inhibits differentiation, which can be rescued by 3-phosphoglycerate supplementation.
- The study underscores the significance of compartmentalized metabolism in cell fate decisions.