Efficacy, immunogenicity, and safety of BCG revaccination against Mycobacterium tuberculosis: A systematic review and meta-analysis - PubMed
7 days ago
- #Tuberculosis
- #Immunogenicity
- #BCG vaccination
- BCG revaccination's efficacy, immunogenicity, and safety were evaluated in a systematic review and meta-analysis.
- No significant effect of BCG revaccination on initial or sustained QFT conversion was found, showing only modest effectiveness against Mycobacterium tuberculosis.
- Immunogenicity evaluation showed a moderate increase in CD8+ T cell and cytokine-producing CD4+ T cell responses.
- Safety analysis indicated increased adverse events but a reduced risk of upper respiratory tract infections.
- Results suggest limited benefit of BCG revaccination in high-risk groups and highlight the need for vaccines with proven protective immunity.