Hierarchical Zeolitic Imidazolate Framework-8@Au Cluster Nanocarriers for In Situ Chimeric Antigen Receptor Macrophage Programming and Immunotherapy in Prostate Cancer - PubMed
6 hours ago
- #CAR-macrophage
- #prostate cancer
- #nanocarriers
- A hierarchical ZIF-8@Au nanocarrier system is developed for delivering CAR genes and IFN-γ to prostate cancer tumors.
- The nanocarrier targets tumor-associated macrophages (TAMs), enabling in situ programming of CAR-macrophages (CAR-Ms) without ex vivo manufacturing.
- Co-delivery of IFN-γ enhances CAR-M tumor-killing, phagocytosis, and adaptive immunity, achieving 95.54% tumor growth inhibition in a mouse model.
- This approach addresses limitations of CAR-T therapy in solid tumors by overcoming immunosuppressive microenvironments and T cell fitness issues.