Low-fat dietary pattern and dementia mortality: a secondary analysis of the Women's Health Initiative dietary modification randomized clinical trial with long-term follow-up - PubMed
4 hours ago
- #Women's Health Initiative
- #Dementia Mortality
- #Low-Fat Diet
- A low-fat dietary pattern intervention did not reduce dementia mortality in postmenopausal women.
- The Women's Health Initiative randomized trial included 48,835 women aged 50-79, comparing a low-fat diet to usual diet over a median 8.5-year intervention and 20-year follow-up.
- No significant association was found between the dietary intervention and dementia mortality (HR: 0.94, 95% CI: 0.85-1.05), nor for Alzheimer's or non-Alzheimer's dementia mortality.
- Subgroup analysis showed a trend toward lower dementia mortality in younger women (50-59 years), though results were not statistically significant.
- The dietary intervention previously reduced breast cancer mortality and lowered possible cognitive impairment in women aged 65+ in the WHI study.