Thalamic activation of the visual cortex at the single-synapse level - PubMed
4 hours ago
- #Thalamocortical activation
- #Visual cortex
- #Single-synapse level
- Study explores thalamocortical activation in mouse primary visual cortex at single-synapse level.
- Used two-photon glutamate imaging and optogenetic cortical silencing in vivo to identify thalamocortical synapses.
- Found thalamocortical-recipient spines lack postsynaptic Ca2+ signals, unlike corticocortical-recipient spines.
- Results validate the Hubel and Wiesel feedforward model for orientation selectivity emergence.
- Highlights distinct synaptic properties key for cortical computation and plasticity.